Quantifying Allele-Specific CRISPR Editing Activity with CRISPECTOR2.0

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The authors introduced CRISPECTOR2.0, with an allele-specific editing activity quantification option. CRISPECTOR2.0 enabled reference-free, allele-aware, precise quantification of on- and off-target activity, by using de novo sample-specific single nucleotide variant (SNV) detection and statistical-based allele-calling algorithms.
[Nucleic Acids Research]
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