Integrated Drug Resistance and Leukemic Stemness Gene-Expression Scores Predict Outcomes in Large Cohort of Over 3500 AML Patients from 10 Trials

Investigators leveraged machine-learning tools by evaluating expression of genes of pharmacological relevance to standard-AML chemotherapy in a discovery-cohort of pediatric AML patients and defined a 5-gene-drug resistance score that was predictive of outcome.