NNMT Switches the Proangiogenic Phenotype of Cancer-Associated Fibroblasts via Epigenetically Regulating ETS2/VEGFA Axis

Scientists showed that nicotinamide N’-methyltransferase (NNMT) in fibroblasts contributed to angiogenesis and tumor growth through an epigenetic reprogramming-ETS2-VEGFA signaling axis in oral squamous cell carcinoma.