Local Receptor-Interacting Protein Kinase 2 Inhibition Mitigates HDM-Induced Asthma

Researchers evaluated the effectiveness of a pharmacological RIPK2 inhibitor administered locally as a preventive and therapeutic approach using a house dust mite-induced asthma model in wild-type and humanized mice harbouring an asthma associated risk allele, and its relevance using airway liquid interface epithelial cultures from asthmatics.