Targeting miR-29 Mitigates Skeletal Senescence and Bolsters Therapeutic Potential of Mesenchymal Stromal Cells

The authors reported increased miR-29 expression in bone tissues of aged mice, osteoporotic patients, and senescent MSCs. Genetic overexpression of miR-29 in Prx1-positive MSCs significantly accelerated skeletal senescence, reducing cortical bone thickness and trabecular bone mass, while increasing femur cross-sectional area, bone marrow adiposity, p53, and senescence-associated secretory phenotype levels.