Secreted Factors from M1 Macrophages Drive Prostate Cancer Stem Cell Plasticity by Upregulating NANOG, SOX2, and CD44 Through NFκB-Signaling

Researchers investigated the influence of pro-inflammatory (M1) and immunosuppressive macrophages on prostate cancer lineage plasticity. Their findings revealed that M1 macrophage-secreted factors upregulated genes related to stemness while downregulating genes associated with androgen response in prostate cancer cells.