Endogenous Osteoprotegerin (OPG) Represses ERα and Promotes Stemness and Chemoresistance in Breast Cancer Cells

Researchers demonstrated that ectopic expression of OPG in breast epithelial/cancer cells promoted the pro-metastatic processes epithelial-to-mesenchymal transition, stemness, angiogenesis as well as the activation of breast stromal fibroblasts.