Polymorphism in the Hsa-miR-4274 Seed Region Influences the Expression of PEX5 and Enhances Radiotherapy Resistance in Colorectal Cancer

To investigate the molecular mechanism of the genetic variation and its impact on the radiosensitivity of colorectal cancer, bioinformatics analysis was combined with functional experiments to confirm peroxisomal biogenesis factor 5 (PEX5) as a direct target of miR-4274.