An Isoform-Resolution Transcriptomic Atlas of Colorectal Cancer from Long-Read Single-Cell Sequencing

Investigators integrated short- and long-read scRNA-seq of colorectal cancer (CRC) samples to build an isoform-resolution CRC transcriptomic atlas. They identified 394 dysregulated transcript structures in tumor epithelial cells, including 299 resulting from various combinations of splicing events.