Talin2 Binds to Non-Muscle Myosin IIa and Regulates Cell Attachment and Fibronectin Secretion

Overexpression of non-muscle myosin IIA (NMIIA) promoted the talin2 head binding to the β1-integrin tail, whereas knockdown of NMIIA reduced fibronectin and matrix metalloproteinase secretion as well as inhibited cell attachment on fibronectin-coated substrates.