Histone H3.3 Lysine 9 and 27 Control Repressive Chromatin at Cryptic Enhancers and Bivalent Promoters

Scientists mutated histone H3.3 K9 and K27 residues in mouse embryonic stem cells. They found that H3.3K9 was essential for controlling specific distal intergenic regions and for proper H3K27me3 deposition at promoters.