Discovery of SARS-CoV-2 Papain-Like Protease (PL^pro) Inhibitors with Efficacy in a Murine Infection Model

Investigators reported the machine learning–driven discovery of potent, selective, and orally available SARS-CoV-2 PLpro inhibitors, with lead compound PF-07957472 providing robust efficacy in a mouse-adapted model of COVID-19 infection.