HIF-2α Drives Hepatic Kupffer Cell Death and Proinflammatory Recruited Macrophage Activation in Nonalcoholic Steatohepatitis

Researchers showed that hypoxia-inducible factor 2α (HIF-2α) mediated nonalcoholic steatohepatitis-associated decreased Kupffer cell growth and efferocytosis by enhancing lysosomal stress.