The Metabolic Profiles of Endogenous and Exogenous Substances in a Poor Metabolizer of Humanized CYP2D6 Model

Investigators used embryonic stem cell targeting and CRISPR-Cas9 technology to create a humanized CYP2D6 mouse model by inserting the human wild-type CYP2D6 gene and knocking out the mouse Cyp2d locus.