Cellular Calcium Handling and Electrophysiology Are Modulated by Chronic Physiological Pacing in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Researchers studied the effects of electric pacing for 24 hours or 7 days at a physiological rate of 60 bpm on cellular electrophysiology and Ca²⁺-cycling in late-stage, differentiated human induced pluripotent stem cell-derived cardiomyocytes.