Extrachromosomal Circular DNA-Related SPOCK1 Contributes to Development and Enzalutamide Resistance of Prostate Cancer by Regulating Epithelial Mesenchymal Transition

Investigators used Circle-seq and studied the distribution pattern and expression level of eccDNA in prostate cancer. They confirmed that eccDNA is derived from every human chromosome and has sequences from all known types of genomic structures, revealing it is a common mutational element in prostate cancer.