MARCH8 Mediates K27-Linked Polyubiquitination of IL-7 Receptor α to Negatively Regulate IL-7–Triggered T Cell Homeostasis

Scientists showed that the membrane-associated RING-CH (MARCH) E3 ligase family member MARCH8 mediated K27-linked polyubiquitination of IL-7Rα, leading to its lysosomal degradation.