SIN3B Loss Heats Up Cold Tumor Microenvironment to Boost Immunotherapy in Pancreatic Cancer

Using murine pancreatic ductal adenocarcinoma models, investigators found that tumor cell-intrinsic Sin3B loss reshaped the tumor microenvironment, increasing CD8+ T cell infiltration and cytotoxicity, thus impeding tumor progression and enhancing sensitivity to anti-PD1 treatment.