At the Interface of Tumor-Associated Macrophages and Fibroblasts: Immune-Suppressive Networks and Emerging Exploitable Targets

Scientists examine the complexity of tumor-associated macrophages (TAM)-cancer-associated fibroblasts (CAF) and CAF-TAM interactions within the tumor microenvironment of solid cancers, with particular focus on ligand-receptor interactions and clinically significant targets for novel therapeutic strategies.