Autoantibodies Neutralizing Type I IFNs Underlie Severe Tick-Borne Encephalitis in ∼10% of Patients

Researchers showed that ∼10% of patients hospitalized for severe tick-borne encephalitis (TBE) carried auto-Abs neutralizing IFN-α2, -β, and/or -ω at the onset of disease, contrasting with only ∼1% of patients with moderate and mild TBE.