Modeling Primary Microcephaly with Human Brain Organoids Reveals Fundamental Roles of CIT Kinase Activity

To investigate human-specific mechanisms of CIT microcephaly, researchers generated CITKI/KI and CITFS/FS human forebrain organoids. They found that CITKI/KI and CITFS/FS organoids lost cytoarchitectural complexity, transitioning from pseudostratified to simple neuroepithelium.