Poly-GP Accumulation Due to C9orf72 Loss of Function Induces Motor Neuron Apoptosis Through Autophagy and Mitophagy Defects

To recapitulate C9orf72-related ALS disease in vivo, scientists developed a zebrafish model where they expressed glycine-proline (GP) dipeptide-repeats in a c9orf72 knockdown context.