Multidimensional Profiling of Human T Cells Reveals High CD38 Expression, Marking Recent Thymic Emigrants and Age-Related Naive T Cell Remodeling

Analysis of single-cell RNA-seq/ATAC-seq data distinguished recent thymic emigrants (RTEs) by the expression of SOX4, IKZF2, and TOX and CD38 protein, whereby surface CD38hi expression universally identified CD8+ and CD4+ RTEs.