Dysregulation of miRNA Expression and Excitation in MEF2C Autism Patient hiPSC-Neurons and Cerebral Organoids

Scientists developed patient human induced pluripotent stem cell-derived cerebrocortical neurons and cerebral organoids to characterize MEF2C haploinsufficiency syndrome deficits. Unexpectedly, they found that decreased neurogenesis was accompanied by activation of a miRNA-mediated gliogenesis pathway.