Alzheimer’s Disease-Linked Risk Alleles Elevate Microglial cGAS-Associated Senescence and Neurodegeneration in a Tauopathy Model

Scientists combined apolipoprotein E and triggering receptor expressed on myeloid cells 2 (TREM2R47H) in female P301S tauopathy mice to identify the pathways activated when Alzheimer’s disease risk is the strongest, thereby highlighting detrimental disease mechanisms.