RNA Binding Protein ZCCHC24 Promotes Tumorigenicity in Triple-Negative Breast Cancer

The authors identified the RNA-binding protein ZCCHC24 as enriched in the mesenchymal-like TNBC population. ZCCHC24 promoted the expression of a set of genes related to tumorigenicity and treatment resistance by directly binding to the cis-element “UGUWHWWA” in their mRNAs, thereby stabilizing them.