KRAS-Mediated Upregulation of CIP2A Promotes Suppression of PP2A-B56α to Initiate Pancreatic Cancer Development

Scientists demonstrated that KRASG12D induced the expression of an endogenous inhibitor of protein phosphatase 2A (PP2A) activity, cancerous inhibitor of PP2A (CIP2A), and phosphorylation of the PP2A substrate, c-MYC.