microRNA-2117 Negatively Regulates Liver Cancer Stem Cells Expansion and Chemoresistance Via Targeting SOX2

Researchers showed that miR-2117 was downregulated in liver cancer stem cells (CSCs) and predicted the poor prognosis of hepatocellular carcinoma patients. Biofunction studies found that knockdown miR-2117 facilitates liver CSCs self-renewal and tumorigenesis.