Researchers discovered that monoacylglycerol O-Acyltransferase 3 (MOGAT3) mediated diacylglycerol (DAG) accumulation contributed to acquired resistance to encorafenib/cetuximab by dissecting BRAFV600E-mutant metastatic colorectal cancer patient-derived xenograft model exposed to encorafenib/cetuximab administration.
[Journal of Clinical Investigation]