AKAP12 Positive Fibroblast Determines Immunosuppressive Contexture and Immunotherapy Response in Patients with TNBC by Promoting Macrophage M2 Polarization

Multiomics analyses were applied to identify the cancer-associated fibroblasts (CAFs)-specific genes related to immunotherapy response. The clinical significance of a CAFs subset with A-kinase anchoring protein 12 (AKAP12) positive was explored in 80 patients with triple-negative breast cancer through double-labeling immunofluorescence assay.