S-RBD-Modified and miR-486-5p-Engineered Exosomes Derived from Mesenchymal Stem Cells Suppress Ferroptosis and Alleviate Radiation-Induced Lung Injury and Long-Term Pulmonary Fibrosis

The authors developed an engineered MSC-derived exosomes with SARS-CoV-2-S-RBD- and miR-486-5p- modification and investigated their intervention effects on radiation-induced lung fibrosis and action mechanisms via suppression of epithelial cell ferroptosis.