Combined Targeting of GPX4 and BCR-ABL Tyrosine Kinase Selectively Compromises BCR-ABL+ Leukemia Stem Cells

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Investigators demonstrated that Disulfiram induced ferroptosis to synergize with TKIs in inhibiting BCR-ABL+ cells, particularly targeting resistant cells and leukemia stem cells, using cell models, mouse models, and primary cells from patients.
[Molecular Cancer]
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