Pseudomonas aeruginosa Faces a Fitness Trade-Off Between Mucosal Colonization and Antibiotic Tolerance During Airway Infection

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Scientists investigated P. aeruginosa growth and antibiotic tolerance in tissue-engineered airways by transposon insertion sequencing. Metabolic modelling based on Tn-seq data revealed the nutritional requirements for P. aeruginosa growth, highlighting reliance on glucose and lactate and varying requirements for amino acid biosynthesis.
[Nature Microbiology]
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