A Biodegradable Lipid Nanoparticle Delivers a Cas9 Ribonucleoprotein for Efficient and Safe In Situ Genome Editing in Melanoma

Investigators designed multifunctional cationic lipid nanoparticles specifically tailored for the efficient delivery of Cas9 ribonucleoprotein complexes targeting the mouse Braf gene through transdermal delivery, aiming to treat mouse melanoma.