Modeling Tumor-Immune Interactions Using Hybrid Spheroids and Microfluidic Platforms for Studying Tumor-Associated Macrophage Polarization in Melanoma

Using a 3D hybrid spheroid system consisting of murine melanoma cells and macrophages, scientists developed a miniaturized tumor microenvironment (TME) model to explore interactions between cancer cells with different metastatic potential and macrophages in the TME.