Neuronal Cathepsin S Increases Neuroinflammation and Causes Cognitive Decline via CX3CL1-CX3CR1 Axis and JAK2-STAT3 Pathway in Aging and Alzheimer’s Disease

Researchers investigated the role of neuronal cathepsin S (CTSS) in aging and Alzheimer’s disease started by examining CTSS expression in hippocampus neurons of aging mice and identified a significant increase, which was negatively correlated with recognition abilities.