VRAC Complex Modulates Mechano-Electrical Signal Responses in Human Airway Smooth Muscle Shortening

Researchers explored the physiological role of volume-regulated anion channel (VRAC) in excitation-contraction coupling and shortening of human airway smooth muscle (HASM). In HASM cells, pharmacological inhibition of VRAC with DCPIB markedly attenuated swell-activated Cl– conductance and contractile agonist-induced cellular stiffening as measured by single-cell patch clamp and optical magnetic twisting cytometry, respectively.