Maturation and Persistence of CAR T Cells Derived from Human Pluripotent Stem Cells via Chemical Inhibition of G9a/GLP

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Using a stroma-free human iPSC-T cell differentiation platform, researchers screened for epigenetic modulators that influenced T cell specification and identified the H3K9-directed histone methyltransferases G9a/GLP as repressors of T cell fate.
[Cell Stem Cell]
AbstractGraphical Abstract