Eosinophils Mitigate Intestinal Fibrosis While Promoting Inflammation in a Chronic DSS Colitis Model and Co-Culture Model with Fibroblasts

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Scientists stimulated fibroblasts with active eosinophils or with Eosinophil Cationic Protein (ECP), and assessed fibroblast activation via flow cytometry and immunocytochemistry. They observed decreased fibroblast activation when fibroblasts were co-cultured with active eosinophils or after stimulation with ECP in comparison to monoculture conditions.
[Scientific Reports]
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