RNF4 Mediated Degradation of PDHA1 Promotes Colorectal Cancer Metabolism and Metastasis

The authors investigated the role of RNF4-mediated ubiquitination and degradation of PDHA1 in CRC metabolism and metastasis. Integrating TCGA and Clinical Proteomic Tumor Analysis Consortium databases, proteomic, clinical, and metabolomic analyses were performed, revealing PDHA1 as a prognostic marker in CRC.