Nuclear IMPDH2 Controls the DNA Damage Response by Modulating PARP1 Activity

Scientists identified inosine monophosphate dehydrogenase 2 (IMPDH2), a metabolic enzyme known for its role in catalyzing the rate-limiting step in the de novo biosynthesis of guanine nucleotides, as a chromatin partner of poly(ADP-ribose) polymerase (PARP) 1.