Impairing Ferroptosis through the PI3K/Akt/Nrf2 Pathway: The Way for Nerve Growth Factor to Mitigate Hypoxia-induced Cardiomyocyte Damage

In H9C2 cells, exposure to hypoxia for 24 hours led to weakened nerve growth factor level, as well as lowered cell vitality and superoxide dismutase activity, but elevated levels of LDH, Fe2+, malondialdehyde, and reactive oxygen species, triggering ferroptosis.