Natural Killer Cells Are Required for the Recruitment of CD8+ T Cells and the Efficacy of Immune Checkpoint Blockade in Melanoma Brain Metastases

Researchers demonstrated that NK cells underpin the efficacy of combined PD-1/CTLA-4 blockade in brain metastases by orchestrating the “responder” molecular profile in tumors, and by controlling the intratumoral abundance of CD8+ T cells through regulation of multiple key molecular mediators of T cell trafficking.