WAC Facilitates Mitophagy-mediated MSC Osteogenesis and New Bone Formation via Protecting PINK1 from Ubiquitination-Dependent Degradation

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Scientists revealed that the levels of WW domain-containing coiled-coil adaptor (WAC) were diminished in both osteoporosis patients and osteoporosis mouse models. It played a pivotal function in facilitating MSC osteogenesis and enhancing new bone formation both in vitro and in vivo.
[Advanced Science]
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