ACSS1-Dependent Acetate Utilization Rewires Mitochondrial Metabolism to Support AML and Melanoma Tumor Growth and Metastasis

Scientists reported that acetyl-CoA synthetases (ACSS) 1 and 2 were differentially expressed in cancer. ACSS1 knockdown decreased acute myeloid leukemia burden in vivo and inhibited melanoma tumor and metastatic growth.