Macrophage Depletion in Inflamed Rat Knees Prevents the Activation of Synovial Mesenchymal Stem Cells by Weakening Nampt and Spp1 Signaling

Acute inflammation was induced in rat knee joints by injection of carrageenan. Clodronate liposomes were administered intra-articularly on days 1 and 4 to deplete macrophages, with empty liposomes as a control.