PGC-1α Drives Small Cell Neuroendocrine Cancer Progression Toward an ASCL1-Expressing Subtype with Increased Mitochondrial Capacity

Analyses using a human prostate tissue-based small cell neuroendocrine transformation system showed that the achaete-scute homolog 1 (ASCL1) subtype heightened PGC-1α expression and oxidative phosphorylation activity.