CD70 CAR T Cells Secreting an Anti-CD33/Anti-CD3 Dual Targeting Antibody Overcome Antigen Heterogeneity in AML

Scientists found that CD33 T cell engaging antibody molecules mediated specific cytotoxicity across AML cell lines, including CD33 or CD70 single-antigen knockout tumors. 7033 CAR-T cells eradicated tumor in an in vivo mixed tumor model of CD70 antigen escape.