USP10 Deubiquitinates and Stabilizes CD44 Leading to Enhanced Breast Cancer Cell Proliferation, Stemness and Metastasis

While USP10 depletion prominently downregulated CD44 protein levels and functions, its overexpression significantly enhanced CD44 protein levels, leading to enhanced cluster tumor cell formation, stemness, and metastasis in breast cancer cells both in vitro and ex vivo in primary human breast tumor cells.