METTL14 Suppresses the Expression of YAP1 and the Stemness of Triple-Negative Breast Cancer

Researchers presented an epi-transcriptional mechanism that maintained Hippo-independent YAP1 signaling and played a role in preserving the undifferentiated state of triple-negative breast cancer (TNBC), which indicated the potential for targeting the LSD1-METTL14 axis to address TNBC stemness.